I would like askto ask you two questions,. I hope explainyou can can answer me easily because I am not good at English.

What's the difference between " Of my life" and "In my life" ?

There are few phrases that use these words:

The story of my life. -> when you talk about your entire life story. Or is used to sarcastically answer someone else talking about their pain or complaints that you also have.

I am at the end of my life. -> You are about to actually die or you are exagerating .

It is at the end of its life. -> Something is about to die or about to break.

I never heard of/seen such a thing in my life. -> to exagerate the rudest thing you just heard or saw.

I want you in my life. -> You strongly want the person to be with you.

What's the difference between "I speakoke to a friend" and " I speakoke with a friend" ?

They mean the same thing just written differently.

I would like to ask two questions, I hope you explain to me easily because I am not good atin English.

What's the difference between "I speak to a friend" and " I speak with a friend" ?