In the proposed fluorinated analog (3), Fluorine is expected to exert conformational control over the bond due to the gauche effect and electrostatic interactions.
 The interaction between fluorine substitute and nitrogen atoms brings about two effects to the molecule:(1) stabiliz ing the whole molecule, and (2) increas ing the selectivity towards the target receptors by rigidifying the structure.
Depending on the context for this writing, having the (1) and (2) might be odd. It could be better to say "first, it stabilizies... and, second, it increases..." instead
I don't have enough background to understand the content, so I just commented on the grammar / style. I hope this helps!
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